Epigenetics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392256/
http://www.nature.com/nature/journal/v335/n6186/abs/335142a0.html
http://news.wisc.edu/study-reveals-gene-expression-changes-with-meditation/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822875/
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(12)00005-8

Exercise

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(12)00503-7
http://link.springer.com/article/10.2165/00007256-200232010-00003
http://journals.lww.com/acsm-essr/Abstract/2008/04000/Metabolic_Adaptations_to_Short_term_High_Intensity.3.aspx
http://jap.physiology.org/content/111/6/1554.short
http://link.springer.com/article/10.1007/s004210050119
http://jap.physiology.org/content/102/4/1439.short
http://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2013-0187#.WJyffBiZNsM

Toxins promoting Cancer


Wild CP, Gong YY. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis. 2010 Jan;31(1):71-82.

  1. Magnussen A, Parsi MA. Aflatoxins, hepatocellular carcinoma and public health. World J Gastro. 2013;19(10):1508-12.
  2. Belpomme D, Irigaray P, Hardell L, et al. The multitude and diversity of environmental carcinogens. Environ Res. 2007 Nov;105(3):414-29.
  3. Hung LJ, Chan TF, Wu CH, Chiu HF, Yang CY. Traffic air pollution and risk of death from ovarian cancer in Taiwan: fine particulate matter (PM2.5) as a proxy marker. J Toxicol Environ Health A. 2012;75(3):174-82.
  4. Rezg R, El-Fazaa S, Gharbi N, Mornagui B. Bisphenol A and human chronic diseases: current evidences, possible mechanisms, and future perspectives. Environ Int. 2014 Mar;64:83-90.
  5. Singh R, Gautam N, Mishra A, Gupta R. Heavy metals and living systems: An overview. Indian J Pharmacol. 2011 May;43(3):246-53.
  6. Murgueytio AM, Evans RG, Roberts D. Relationship between soil and dust lead in a lead mining area and blood lead levels. J Expo Anal Environ Epidemiol. 1998 Apr-Jun;8(2):173-86.
  7. Selevan SG, Landrigan PJ, Stern FB, Jones JH. Mortality of lead smelter workers. Am J Epidemiol. 1985 Oct;122(4):673-83.
  8. Edwards VC, Coppock RW, Zinn LL. Toxicoses related to the petroleum industry. Vet Hum Toxicol. 1979 Oct;21(5):328-37.
  9. Aktar MW, Sengupta D, Chowdhury A. Impact of pesticides use in agriculture: their benefits and hazards. Interdiscip Toxicol. 2009 Mar;2(1):1-12.
  10. Schecter A, Startin J, Wright C, et al. Dioxins in U.S. food and estimated daily intake. Chemosphere. 1994 Nov-Dec;29(9-11):2261-5.
  11. Rauscher-Gabernig E, Mischek D, Moche W, Prean M. Dietary intake of dioxins, furans and dioxin-like PCBs in Austria. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(10):1770-9.
  12. Paoli D, Giannandrea F, Gallo M, et al. Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk. J Endocrinol Invest. 2015 Mar 15.
  13. Ananthaswamy HN, Pierceall WE. Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol. 1990 Dec;52(6):1119-36.
  14. Gandhi G, Kaur G, Nisar U. A cross-sectional case control study on genetic damage in individuals residing in the vicinity of a mobile phone base station. Electromagn Biol Med. 2014 Jul 9:1-11.
  15. Hou Q, Wang M, Wu S, et al. Oxidative changes and apoptosis induced by 1800-MHz electromagnetic radiation in NIH/3T3 cells. Electromagn Biol Med. 2015 Mar;34(1):85-92.
  16. Liu C, Duan W, Xu S, et al. Exposure to 1800 MHz radiofrequency electromagnetic radiation induces oxidative DNA base damage in a mouse spermatocyte-derived cell line. Toxicol Lett. 2013 Mar 27;218(1):2-9.
  17. Liu C, Gao P, Xu SC, et al. Mobile phone radiation induces mode-dependent DNA damage in a mouse spermatocyte-derived cell line: a protective role of melatonin. Int J Radiat Biol. 2013 Nov;89(11):993-1001.
  18. Volkow ND, Tomasi D, Wang GJ, et al. Effects of cell phone radiofrequency signal exposure on brain glucose metabolism. Jama. 2011 Feb 23;305(8):808-13.
  19. Hardell L, Carlberg M, Hansson Mild K. Pooled analysis of two case-control studies on the use of cellular and cordless telephones and the risk of benign brain tumours diagnosed during 1997-2003. Int J Oncol. 2006 Feb;28(2):509-18.
  20. Gonzalez-Hunt CP, Leung MC, Bodhicharla RK, et al. Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. PLoS One. 2014;9(12):e114459.
  21. Jarvis IW, Dreij K, Mattsson A, Jernstrom B, Stenius U. Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment. Toxicology. 2014 Jul 3;321:27-39.
  22. Deziel NC, Rull RP, Colt JS, et al. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environ Res. 2014 Aug;133:388-95.
  23. Hew KM, Walker AI, Kohli A, et al. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clin Exp Allergy. 2015 Jan;45(1):238-48.
  24. Rota M, Bosetti C, Boccia S, Boffetta P, La Vecchia C. Occupational exposures to polycyclic aromatic hydrocarbons and respiratory and urinary tract cancers: an updated systematic review and a meta-analysis to 2014. Arch Toxicol. 2014 Aug;88(8):1479-90.
  25. Safe SH. Environmental and dietary estrogens and human health: is there a problem? Environ Health Perspect. 1995 Apr;103(4): 346-51.
  26. Schaal C, Chellappan SP. Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res. 2014 Jan;12(1):14-23.
  27. Graham B, Stevens J, Wells P, et al. Enhancement of arsenic trioxide-mediated changes in human induced pluripotent stem cells (IPS). Int J Environ Res Public Health. 2014 Jul;11(7):7524-36.
  28. Xin F, Jiang L, Liu X, et al. Bisphenol A induces oxidative stress-associated DNA damage in INS-1 cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Jul 15;769:29-33.
  29. Belyaev IY, Hillert L, Protopopova M, et al. 915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons. Bioelectromagnetics. 2005 Apr;26(3):173-84.
  30. De Iuliis GN, Newey RJ, King BV, Aitken RJ. Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro. PLoS One. 2009;4(7):e6446.
  31. Huffnagle IM, Joyner A, Rumble B, Hysa S, Rudel D, Hvastkovs EG. Dual electrochemical and physiological apoptosis assay detection of in vivo generated nickel chloride induced DNA damage in Caenorhabditis elegans. Anal Chem. 2014 Aug 19;86(16):8418-24.
  32. Ames BN, Gold LS. Natural chemicals, synthetic chemicals, risk assessment, and cancer. Princess Takamatsu Symp. 1990;21:303-14.
  33. Gomez-Martin A, Altakroni B, Lozano-Paniagua D, et al. Increased N7-methyldeoxyguanosine DNA adducts after occupational exposure to pesticides and influence of genetic polymorphisms of paraoxonase-1 and glutathione S-transferase M1 and T1. Environ Mol Mutagen. 2014 Nov 26.
  34. How V, Hashim Z, Ismail P, Md Said S, Omar D, Bahri Mohd Tamrin S. Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children. J Agromedicine. 2014;19(1):35-43.
  35. Waters MD, Stack HF, Jackson MA, Brockman HE, De Flora S. Activity profiles of antimutagens: in vitro and in vivo data. Mutat Res. 1996 Feb 19;350(1):109-29.
  36. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY. Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. Int J Cancer. 2006 Jun 1;118(11):2665-71.
  37. Barouki R, Morel Y. Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological implications. Biochem Pharmacol. 2001 Mar 1;61(5):511-6.
  38. Kleman MI, Overvik E, Poellinger L, Gustafsson JA. Induction of cytochrome P4501A isozymes by heterocyclic amines and other food-derived compounds. Princess Takamatsu Symp. 1995;23:163-71.
  39. Foth H. Role of the lung in accumulation and metabolism of xenobiotic compounds–implications for chemically induced toxicity. Crit Rev Toxicol. 1995;25(2):165-205.
  40. Vetvicka V, Vetvickova J. Glucan-resveratrol-vitamin C combination offers protection against toxic agents. Toxins (Basel). 2012 Nov;4(11):1301-8.
  41. Turner PC, Flannery B, Isitt C, Ali M, Pestka J. The role of biomarkers in evaluating human health concerns from fungal contaminants in food. Nutr Res Rev. 2012 Jun;25(1):162-79.
  42. Mehta H, Nazzal K, Sadikot RT. Cigarette smoking and innate immunity. Inflamm Res. 2008 Nov;57(11):497-503.
  43. Balabanic D, Rupnik M, Klemencic AK. Negative impact of endocrine-disrupting compounds on human reproductive health. Reprod Fertil Dev. 2011;23(3):403-16.
  44. Ferreira LL, Couto R, Oliveira PJ. Bisphenol A as epigenetic modulator: setting the stage for carcinogenesis? Eur J Clin Invest. 2015 Jan;45 Suppl 1:32-6.
  45. Hussain I, Bhan A, Ansari KI, et al. Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer. Biochim Biophys Acta. 2015 Feb 25.
  46. Fang CC, Chen FY, Chen CR, et al. Cyprodinil as an activator of aryl hydrocarbon receptor. Toxicology. 2013 Feb 8;304:32-40.
  47. Pestana D, Teixeira D, Faria A, Domingues V, Monteiro R, Calhau C. Effects of environmental organochlorine pesticides on human breast cancer: putative involvement on invasive cell ability. Environ Toxicol. 2015 Feb;30(2):168-76.
  48. Villeneuve S, Cyr D, Lynge E, et al. Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case-control study in Europe. Occup Environ Med. 2010 Dec;67(12):837-44.
  49. De Coster S, van Larebeke N. Endocrine-disrupting chemicals: associated disorders and mechanisms of action. J Environ Public Health. 2012;2012:713696.
  50. Erkekoglu P, Kocer-Gumusel B. Genotoxicity of phthalates. Toxicol Mech Methods. 2014 Dec;24(9):616-26.
  51. Tremoen NH, Fowler PA, Ropstad E, Verhaegen S, Krogenaes A. Exposure to the three structurally different PCB congeners (PCB 118, 153, and 126) results in decreased protein expression and altered steroidogenesis in the human adrenocortical carcinoma cell line H295R. J Toxicol Environ Health A. 2014;77(9-11):516-34.
  52. Van Vleet TR, Watterson TL, Klein PJ, Coulombe RA, Jr. Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells. Toxicol Sci. 2006 Feb;89(2):399-407.
  53. Villar S, Le Roux-Goglin E, Gouas DA, et al. Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection. Environ Health Perspect. 2011 Nov;119(11):1635-40.
  54. Zhang YJ, Rossner P, Jr., Chen Y, et al. Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients. Int J Cancer. 2006 Sep 1;119(5):985-91.
  55. Sandoval M, Morales M, Tapia R, et al. p53 response to arsenic exposure in epithelial cells: protein kinase B/Akt involvement. Toxicol Sci. 2007 Sep;99(1):126-40.
  56. Golovine K, Makhov P, Uzzo RG, et al. Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism. Mol Cancer. 2010;9:183.
  57. Yang YX, Li XL, Wang L, et al. Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. Int J Oncol. 2013 Sep;43(3):936-46.
  58. Son YO, Pratheeshkumar P, Roy RV, et al. Nrf2/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis. J Biol Chem. 2014 Oct 10;289(41):28660-75.
  59. Yadava N, Schneider SS, Jerry DJ, Kim C. Impaired mitochondrial metabolism and mammary carcinogenesis. J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):75-87.
  60. Gichuhi S, Ohnuma S, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014 Dec;129:172-82.

Reichrath J, Rass K. Ultraviolet damage, DNA repair and vitamin D in nonmelanoma skin cancer and in malignant melanoma: an update. Adv Exp Med Biol. 2014;810:208-33.

Kim JY, Yi BR, Go RE, Hwang KA, Nam KH, Choi KC. Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway. Environ Toxicol Pharmacol. 2014 May;37(3):1264-74.

Dingley KH, Ubick EA, Chiarappa-Zucca ML, et al. Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr Cancer. 2003;46(2):212-21.

Weill FS, Cela EM, Paz ML, Ferrari A, Leoni J, Gonzalez Maglio DH. Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV-induced carcinogenesis. Br J Nutr. 2013 Feb 14;109(3):457-66.

Platten M, Wick W, Van den Eynde BJ. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res. 2012 Nov 1;72(21):5435-40.

Nutrients Boost immune system

Liu S, Li S, Du Y. Polychlorinated biphenyls (PCBs) enhance metastatic properties of breast cancer cells by activating Rho-associated kinase (ROCK). PLoS One. 2010;5(6):e11272.

  1. Larsen JC. Risk assessments of polychlorinated dibenzo- p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in food. Mol Nutr Food Res. 2006 Oct;50(10):885-96.
  1. Hosnijeh FS, Heederik D, Vermeulen R. A review of the role of lymphoma markers and occupational and environmental exposures. Vet Q. 2012 Jun;32(2):61-73.
  2. Platten M, Wick W, Van den Eynde BJ. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res. 2012 Nov 1;72(21):5435-40.

Chu XT, de la Cruz J, Hwang SG, Hong H. Tumorigenic effects of endocrine-disrupting chemicals are alleviated by licorice (Glycyrrhiza glabra) root extract through suppression of AhR expression in mammalian cells. Asian Pac J Cancer Prev. 2014;15(12):4809-13.

  1. Hamaï A, Benlalam H, Meslin F, Hasmim M, Carré T, Akalay I, Janji B, Berchem G, Noman MZ, Chouaib S. Immune surveillance of human cancer: if the cytotoxic T-lymphocytes play the music, does the tumoral system call the tune? Tissue Antigens. 2010 Jan;75(1):1-8.
  2. Bryden WL. Mycotoxins in the food chain: human health implications. Asia Pac J Clin Nutr. 2007;16 Suppl 1:95-101.
  3. Cholujova D, Jakubikova J, Czako B, et al. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother. 2013 Mar;62(3):437-45.
  4. Ali KH, Melillo AB, Leonard SM, et al. An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults. FFHD. 2012;2(7):265-79.
  5. Bang MH, Van Riep T, Thinh NT, et al. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 2010 Dec;30(12):5145-51.
  6. Revilla E, Santa-Maria C, Miramontes E, et al. Antiproliferative and immunoactivatory ability of an enzymatic extract from rice bran. Food Chem. 2013 Jan 15;136(2):526-31.
  7. Zhang K, Ma X, He W, et al. Extracts of Cistanche deserticola can antagonize immunosenescence and extend life span in senescence-accelerated mouse prone 8 (SAM-P8) mice. Evid Based Complement Alternat Med. 2014;2014:601383.
  8. Zhai Z, Liu Y, Wu L, et al. Enhancement of innate and adaptive immune functions by multiple Echinacea species. J Med Food. 2007 Sep;10(3):423-34.
  9. Jia Y, Guan Q, Guo Y, Du C. Echinacoside stimulates cell proliferation and prevents cell apoptosis in intestinal epithelial MODE-K cells by up-regulation of transforming growth factor-beta1 expression. J Pharmacol Sci. 2012;118(1):99-108.
  10. Jia Y, Guan Q, Guo Y, Du C. Reduction of inflammatory hyperplasia in the intestine in colon cancer prone mice by water-extract of Cistanche deserticola. Phytother Res. 2012 Jun;26(6):812-9.
  11. Katiyar SK. UV-induced immune suppression and photocarcinogenesis: chemoprevention by dietary botanical agents. Cancer Lett. 2007 Sep 18;255(1):1-11.
  12. Mantena SK, Meeran SM, Elmets CA, Katiyar SK. Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J Nutr. 2005 Dec;135(12):2871-7.
  13. Mantena SK, Roy AM, Katiyar SK. Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors. Photochem Photobiol. 2005 Sep-Oct;81(5):1174-9.
  14. Katiyar S, Elmets CA, Katiyar SK. Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair. J Nutr Biochem. 2007 May;18(5):287-96.
  15. Butt MS, Sultan MT. Green tea: nature’s defense against malignancies. Crit Rev Food Sci Nutr. 2009 May;49(5):463-73.
  16. Shimizu K, Kinouchi Shimizu N, Hakamata W, Unno K, Asai T, Oku N. Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice. Biol Pharm Bull. 2010;33(1):117-21.
  17. Weill FS, Cela EM, Paz ML, Ferrari A, Leoni J, Gonzalez Maglio DH. Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV-induced carcinogenesis. Br J Nutr. 2013 Feb 14;109(3):457-66.
  18. De Moreno de Leblanc A, Perdigon G. The application of probiotic fermented milks in cancer and intestinal inflammation. Proc Nutr Soc. 2010 Aug;69(3):421-8.
  19. Zuccotti GV, Meneghin F, Raimondi C, et al. Probiotics in clinical practice: an overview. J Int Med Res. 2008;36 Suppl 1:1a-53a.
  20. Cheuk W, Chan JK, Nuovo G, Chan MK, Fok M. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Int J Surg Pathol. 2007 Apr;15(2):180-6.
  21. Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. Am J Chin Med. 2011;39(1):15-27.
  22. Sun LX, Li WD, Lin ZB, et al. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Cell Physiol Biochem. 2014;33(2):289-99.
  23. Liu YJ, Shen J, Xia YM, Zhang J, Park HS. The polysaccharides from Ganoderma lucidum: Are they always inhibitors on human hepatocarcinoma cells? Carbohydr Polym. 2012 Oct 15;90(3):1210-5.
  24. Hu L, Cao D, Li Y, He Y, Guo K. Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors. Cancer Biol Ther. 2012 May;13(7):516-26.
  25. Noh KT, Chae SH, Chun SH, Jung ID, Kang HK, Park YM. Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun. 2013 Feb 8;431(2):348-53.

Hopkins MH, Owen J, Ahearn T, et al. Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorectal adenoma patients: a randomized, controlled clinical trial. Cancer Prev Res (Phila). 2011 Oct;4(10):1645-54.

The Science of Detoxification

Hawas UW, Gamal-Eldeen AM, El-Toumy SA, Meyer JJ, Hussein AA. Inhibition of the initiation stage of carcinogenesis by Salvia disermas constituents. Z Naturforsch C. 2009 Nov-Dec;64(11-12):831-9.

Srivastava DS, Mandhani A, Mittal RD. Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India. Arch Toxicol. 2008 Sep;82(9):633-9.

Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr. 2005 Jan;81(1 Suppl):215S-217S.

  1. Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J Cell Biochem Suppl. 1995;22:169-80.Liska DJ. The detoxification enzyme systems. Altern Med Rev. 1998 Jun;3(3):187-98. Review.
  2. Talalay P, Prochaska HJ, Spencer SR. Regulation of enzymes that detoxify the electrophilic forms of chemical carcinogens. Princess Takamatsu Symp. 1990;21:177-87.
  3. Sweeney BP, Bromilow J. Liver enzyme induction and inhibition: implications for anaesthesia. Anaesthesia. 2006 Feb;61(2):159-77.
  4. Pullar JM, Thomson SJ, King MJ, Turnbull CI, Midwinter RG, Hampton MB. The chemopreventive agent phenethyl isothiocyanate sensitizes cells to fas-mediated apoptosis. Carcinogenesis. 2004 May;25(5):765-72.
  5. Wen X, Donepudi AC, Thomas PE, Slitt AL, King RS, Aleksunes LM. Regulation of hepatic Phase II metabolism in pregnant mice. J Pharmacol Exper Ther . 2013;344(1):244-52.
  6. De Figueiredo SM, Filho SA, Nogueira-Machado JA, Caligiorne RB. The anti-oxidant properties of isothiocyanates: a review. Recent Pat Endocr Metab Immune Drug Discov. 2013 Sep;7(3):213-25.
  7. Tortorella SM, Royce SG, Licciardi PV, Karagiannis TC. Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition. Antioxid Redox Signal. 2014 Nov 3.
  9. Rose P, Faulkner K, Williamson G, Mithen R. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8.

Toxins Damaging Effect on DNA

Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22.Helbock HJ, Beckman KB, Shigenaga MK, et al. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):288-93.

  1. Chen JH, Zhang P, Chen WD, et al. ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells. Autophagy. 2015 Feb 20:0.
  2. Rana C, Piplani H, Vaish V, Nehru B, Sanyal SN. Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer. Tumour Biol. 2015 Mar 6.
  3. Tran UM, Rajarajacholan U, Soh J, et al. LincRNA-p21 acts as a mediator of ING1b-induced apoptosis. Cell Death Dis. 2015;6:e1668.
  4. Chen Y, Williams V, Filippova M, Filippov V, Duerksen-Hughes P. Viral carcinogenesis: factors inducing DNA damage and virus integration. Cancers (Basel). 2014;6(4):2155-86.
  5. Weisel T, Baum M, Eisenbrand G, et al. An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnol J. 2006 Apr;1(4):388-97.
  6. Al-Taie OH, Seufert J, Karvar S, et al. Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas. Nutr Cancer. 2003;46(2):125-30.
  7. Dziaman T, Huzarski T, Gackowski D, et al. Selenium supplementation reduced oxidative DNA damage in adnexectomized BRCA1 mutations carriers. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2923-8.
  8. Hu JJ, Chi CX, Frenkel K, et al. Alpha-tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2’-deoxyuridine (HMdU). Cancer Epidemiol Biomarkers Prev. 1999 Aug;8(8):693-8.
  10. Konopacka M. Role of vitamin C in oxidative DNA damage. Postepy Hig Med Dosw (Online). 2004;58:343-8.
  12. Lutsenko EA, Cárcamo JM, Golde DW. Vitamin C prevents DNA mutation induced by oxidative stress. J Biol Chem. 2002 May 10;277(19):16895-9.
  14. Dominici L, Villarini M, Trotta F, Federici E, et al. Protective effects of probiotic Lactobacillus rhamnosus IMC501 in mice treated with PhIP. J Microbiol Biotechnol. 2014 Mar 28;24(3):371-8.
  16. Li H, Liu K, Boardman LA, et al. Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance. EBioMedicine. 2015 Feb 1;2(2):165-71.
  18. Petersen B, Wulf HC, Triguero-Mas M, et al. Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage. J Invest Dermatol. 2014 Nov;134(11):2806-13.
  20. Nair-Shalliker V, Armstrong BK, Fenech M. Does vitamin D protect against DNA damage? Mutat Res. 2012 May 1;733(1-2):50-7.

Using Vitamin Herbs For Disease Prevention

Weisel T, Baum M, Eisenbrand G, et al. An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnol J. 2006 Apr;1(4):388-97.

  1. Al-Taie OH, Seufert J, Karvar S, et al. Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas. Nutr Cancer. 2003;46(2):125-30.
  2. Dziaman T, Huzarski T, Gackowski D, et al. Selenium supplementation reduced oxidative DNA damage in adnexectomized BRCA1 mutations carriers. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2923-8.
  3. Hu JJ, Chi CX, Frenkel K, et al. Alpha-tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2’-deoxyuridine (HMdU). Cancer Epidemiol Biomarkers Prev. 1999 Aug;8(8):693-8.
  4. Konopacka M. Role of vitamin C in oxidative DNA damage. Postepy Hig Med Dosw (Online). 2004;58:343-8.
  5. Lutsenko EA, Cárcamo JM, Golde DW. Vitamin C prevents DNA mutation induced by oxidative stress. J Biol Chem. 2002 May 10;277(19):16895-9.
  6. Dominici L, Villarini M, Trotta F, Federici E, et al. Protective effects of probiotic Lactobacillus rhamnosus IMC501 in mice treated with PhIP. J Microbiol Biotechnol. 2014 Mar 28;24(3):371-8.
  7. Li H, Liu K, Boardman LA, et al. Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance. EBioMedicine. 2015 Feb 1;2(2):165-71.
  8. Petersen B, Wulf HC, Triguero-Mas M, et al. Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage. J Invest Dermatol. 2014 Nov;134(11):2806-13.
  9. Nair-Shalliker V, Armstrong BK, Fenech M. Does vitamin D protect against DNA damage? Mutat Res. 2012 May 1;733(1-2):50-7.
  10. Vaishampayan U, Hussain M, Banerjee M, et al. Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr Cancer. 2007;59(1):1-7.
  11. Zhao X, Aldini G, Johnson EJ, et al. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am J Clin Nutr. 2006 Jan;83(1):163-9.
  12. Nagendraprabhu P, Sudhandiran G. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Invest New Drugs. 2011 Apr;29(2):207-24.
  13. Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010;7:18.
  14. Gao S, Qin T, Liu Z, Caceres MA, Ronchi CF, Chen CY, Yeum KJ, Taylor A, Blumberg JB, Liu Y, Shang F. Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells. Mol Vis. 2011;17:3180-90.
  15. Serpeloni JM, Barcelos GR, Friedmann Angeli JP, Mercadante AZ, Lourdes Pires Bianchi M, Antunes LM. Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human derived HepG2 cells. Toxicol In Vitro. 2012 Mar;26(2):288-94.
  16. Kim JM, Park E. Coenzyme Q10 attenuated DMH-induced precancerous lesions in SD rats. J Nutr Sci Vitaminol (Tokyo). 2010;56(2):139-44.
  17. Reiter M, Rupp K, Baumeister P, Zieger S, Harreus U. Antioxidant effects of quercetin and coenzyme Q10 in mini organ cultures of human nasal mucosa cells. Anticancer Res. 2009 Jan;29(1):33-9.
  18. Sakano K, Takahashi M, Kitano M, Sugimura T, Wakabayashi K. Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats. Asian Pac J Cancer Prev. 2006 Oct-Dec;7(4):599-603.
  19. Kansal S, Bhatnagar A, Agnihotri N. Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-kappaB signaling in colorectal cancer. PLoS One. 2014;9(1):e84627.
  20. Rhodes LE, Shahbakhti H, Azurdia RM, et al. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers. Carcinogenesis. 2003 May;24(5):919-25.
  21. Souza LR, Silva E, Calloway E, Kucuk O, Rossi M, McLemore ML. Genistein protects hematopoietic stem cells against G-CSF-induced DNA damage. Cancer Prev Res (Phila). 2014 May;7(5):534-44.
  22. Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr. 2005 Jan;81(1 Suppl):215S-217S.
  23. Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J Cell Biochem Suppl. 1995;22:169-80.
  24. Wilhelm Filho D, Avila S, Jr., Possamai FP, et al. Antioxidant therapy attenuates oxidative stress in the blood of subjects exposed to occupational airborne contamination from coal mining extraction and incineration of hospital residues. Ecotoxicology. 2010 Oct;19(7):1193-200.
  25. Hu F, Wu Z, Li G, et al. The plasma level of retinol, vitamins A, C and alpha-tocopherol could reduce breast cancer risk? A meta-analysis and meta-regression. J Cancer Res Clin Oncol. 2015 Apr;141(4):601-14.
  26. Liu Y, Yu Q, Zhu Z, et al. Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies. Med Oncol. 2015 Jan;32(1):434.
  27. Venturelli S, Sinnberg TW, Berger A, et al. Epigenetic impacts of ascorbate on human metastatic melanoma cells. Front Oncol. 2014;4:227.
  28. Kim JE, Kang JS, Lee WJ. Vitamin C Induces Apoptosis in Human Colon Cancer Cell Line, HCT-8 Via the Modulation of Calcium Influx in Endoplasmic Reticulum and the Dissociation of Bad from 14-3-3β. Immune Netw. 2012 Oct;12(5):189-95.
  29. Fedirko V, Bostick RM, Long Q, et al. Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):280-91.
  30. Pappachan JM, Antonio FA, Edavalath M, Mukherjee A. Non-alcoholic fatty liver disease: a diabetologist’s perspective. Endocrine. 2014 Apr;45(3):344-53.
  31. Pearlman M, Loomba R. State of the art: treatment of nonalcoholic steatohepatitis. Curr Opin Gastroenterol. 2014 May;30(3):223-37.
  32. Singh S, Singh PP, Roberts LR, Sanchez W. Chemopreventive strategies in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2014 Jan;11(1):45-54.
  33. Sylvester PW, Akl MR, Malaviya A, et al. Potential role of tocotrienols in the treatment and prevention of breast cancer. Biofactors. 2014 Jan-Feb;40(1):49-58.
  34. Hartmann A, Niess AM, Grünert-Fuchs M, Poch B, Speit G. Vitamin E prevents exercise-induced DNA damage. Mutat Res. 1995 Apr;346(4):195-202.

Kline K, Yu W, Sanders BG. Vitamin E and breast cancer. J Nutr. 2004 Dec;134(12 Suppl):3458S-62S.

How Toxins Promote Cancer

  1. National Institutes of Health (US) Biological Sciences Curriculum Study. NIH Curriculum Supplement Series. Bethesda (MD): National Institutes of Health (US); 2007.
  2. Spano D, Heck C, De Antonellis P, Christofori G, Zollo M. Molecular networks that regulate cancer metastasis. Semin Cancer Biol. 2012 Jun;22(3):234-49.
  3. Mihai CT, Rotinberg P, Brinza F, Vochita G. Extremely low-frequency electromagnetic fields cause DNA strand breaks in normal cells. Journal of Environmental Health Science and Engineering. 2014;12:15.
  4. Yakymenko I, Sidorik E. Risks of carcinogenesis from electromagnetic radiation of mobile telephony devices. Exp Oncol. 2010 Jul;32(2):54-60.
  5. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22.
  6. Hawas UW, Gamal-Eldeen AM, El-Toumy SA, Meyer JJ, Hussein AA. Inhibition of the initiation stage of carcinogenesis by Salvia disermas constituents. Z Naturforsch C. 2009 Nov-Dec;64(11-12):831-9.
  7. Srivastava DS, Mandhani A, Mittal RD. Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India. Arch Toxicol. 2008 Sep;82(9):633-9.
  8. Liu S, Li S, Du Y. Polychlorinated biphenyls (PCBs) enhance metastatic properties of breast cancer cells by activating Rho-associated kinase (ROCK). PLoS One. 2010;5(6):e11272.
  9. Larsen JC. Risk assessments of polychlorinated dibenzo- p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in food. Mol Nutr Food Res. 2006 Oct;50(10):885-96.
  10. Hosnijeh FS, Heederik D, Vermeulen R. A review of the role of lymphoma markers and occupational and environmental exposures. Vet Q. 2012 Jun;32(2):61-73.
  11. Platten M, Wick W, Van den Eynde BJ. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res. 2012 Nov 1;72(21):5435-40.
  12. Chu XT, de la Cruz J, Hwang SG, Hong H. Tumorigenic effects of endocrine-disrupting chemicals are alleviated by licorice (Glycyrrhiza glabra) root extract through suppression of AhR expression in mammalian cells. Asian Pac J Cancer Prev. 2014;15(12):4809-13.
  13. Kim JY, Yi BR, Go RE, Hwang KA, Nam KH, Choi KC. Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway. Environ Toxicol Pharmacol. 2014 May;37(3):1264-74.
  14. Wong RL, Walker CL. Molecular pathways: environmental estrogens activate nongenomic signaling to developmentally reprogram the epigenome. Clin Cancer Res. 2013 Jul 15;19(14):3732-7.
  15. Ghebranious N, Sell S. The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice. Hepatology. 1998 Apr;27(4):967-73.
  16. Lee CC, Liu JY, Lin JK, Chu JS, Shew JY. p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions. Cancer Lett. 1998 Mar 13; 125(1-2):1-7.

Farazi PA, Glickman J, Horner J, Depinho RA. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res. 2006 May 1;66(9):4766-73.

  1. Abnet CC. Carcinogenic food contaminants. Cancer Invest. 2007 Apr-May;25(3):189-96.
  2. Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Semin Cancer Biol. 2004 Dec;14(6):473-86.
  3. Hardell L, Sage C. Biological effects from electromagnetic field exposure and public exposure standards. Biomed Pharmacother. 2008 Feb;62(2):104-9.
  4. Morgan LL, Miller AB, Sasco A, Davis DL. Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A) (Review). Int J Oncol. 2015 May;46(5):1865-71.

Sugimura T. Nutrition and dietary carcinogens. Carcinogenesis. 2000 Mar;21(3):387-95.

Vitamin D Protects You From The Cold & Flu

1) In 1991 where they exposed ALL subjects to the cold virus but only those who were “stressed” developed a cold!

Cohen, S. et al. Psychological stress and susceptibility to the common cold. N. Engl. J Med 1991 Aug 29; 325 (9); 606-612.

2) Vitamin D dramatically increases the expression of antimicrobial proteins (AMPs) in cells of the innate immune system (the part of the immune system that immediately attacks and kills viruses, bacteria, and fungi).

Heaney, R. Vitamin D in health and disease. Clin J Am Soc Neph. 2008. Vol 3(5):1535-1541.

3) Countries with the highest blood levels of vitamin D from supplementation have the lowest incidence of seasonal cold and u and half the winter mortality rates.

Cannell, J. et al. Epidemic in uenza and vitamin D. Epidemiol Infect 2006, 134(6):1129-1140.

4) A randomized, double blind, placebo-controlled study reported that children taking Vitamin D3 daily in winter were 67% less likely to get unfluenza (H1N1 varieties).

Urashima, et al. Randomized trial of vitamin D supplementation to prevent seasonal in uenza in schoolchildren. Am J Clin Nutr. May 2010. Vol 91(5):1255-60.

5) In a three year trial supplementing with Vitamin D reduced the incidence of colds and flu by 70%. After two years they increased the amount of vitamin D intake and reached nearly a 100% prevention rate for colds and u (only 1 of 104 subjects developed cold or flu final year).

Aloia, J et al. Epidemic in uenza and vitamin D. Epidemiology and Infection. 2007. Vol 135(7):1095-1098.

6) On the basis of studies reviewed to date, the strongest evidence supports vitamin D therapy for influenza ( u) and viral upper respiratory tract illnesses (colds).”